![]() Ranunculus muricatus L acetylcholinesterase structure elucidation α-glucosidase. Compound 5 displayed moderate cytotoxic activity towards ovarian carcinoma (A2780, IC 50 = 25.4 µM), colorectal adenocarcinoma (HT29, IC 50 = 20.2 µM), breast cancer (MCF7, IC 50 = 23.7 µM), and thyroid carcinoma (SW1736, IC 50 = 26.2 µM) while it was inactive towards pharynx carcinoma (FaDu: IC 50 > 30 µM). Anthraquinone 3 illustrated α-glucosidase inhibitory effects with IC 50-values of 164.46 ± 83.04 µM. Chalcone 1 showed potent acetylcholinesterase inhibitory effects with K i of 5.39 µM and K i' of 3.54 µM, but none of the isolated compounds showed inhibitory activity towards butyrylcholinesterase. Their structures were elucidated using 1D ( 1H and 13C) and 2D (COSY, HSQC, and HMBC) NMR spectroscopy and HR-ESI-MS. muricatus, the new chalcone 4-benzyloxylonchocarpin ( 1), the new anthraquinone muracatanes A ( 2), the new-to-nature anthraquinone muracatanes B ( 3), and the new naphthalene analog muracatanes C ( 4) were isolated, in addition to the three previously reported compounds, 4-methoxylonchocarpin ( 5), β-sitosterol ( 6), and β-sitosterol β-D-glucopyranoside ( 7). is a spiny fruit buttercup that is used in various traditional medicinal systems. 12 Department of Chemistry and Polymer Science, University of Stellenbosch, Private Bag X1, Matieland, Stellenbosch 7600, South Africa. ![]() 11 Department of Biological Sciences and Chemistry, College of Arts and Sciences, University of Nizwa, Nizwa 616, Oman.10 Department of Pharmacognosy (MAPPRC), College of Pharmacy, King Saud University, P.O.Astroworthia is a lesser-known succulent with beautiful green and red, chunky leaves that climb up the stem. Watering Needs: When the soil is completely dried out. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan. Scientific Name: Astroworthia bicarinata. 8 Department of Biology, College of Sciences, Princess Nourah Bint Abdulrahman University, Riyadh 11451, Saudi Arabia.7 Department of Pharmacy, Faculty of Sciences, Tadulako University, Palu 94118, Indonesia.6 Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, 1165 Copenhagen, Denmark.5 Organic Chemistry, Martin-Luther University Halle-Wittenberg, Kurt-Mothes-Str.4 Department of Botany, Government Post Graduate College Parachinar, Parachinar 26300, District Kurram, Pakistan.3 Department of Chemistry, Karakoram International University, Gilgit 15100, Pakistan.2 School of Pharmaceutical Sciences and Key Laboratory for Applied Technology of Sophisticated Analytical Instruments of Shandong Province, Shandong Analysis and Test Center, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250014, China.1 Department of Bioorganic Chemistry, Leibniz Institute of Plant Biochemistry, Weinberg 3, D-06120 Halle (Salle), Germany. ![]()
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